Proteome profiling of cerebrospinal fluid-derived extracellular vesicles reveals potential biomarkers for drug-resistant epilepsy
Proteins with differential abundance studied here are associated with epilepsy due to their potential involvement in critical processes such as neuroprotection, inflammation, cell integrity, and immune response. The observed reduction in the abundance of these proteins in drug-resistant dogs suggests that disruptions in these processes may contribute to the severity of the condition and its resistance to treatment. Results from this pilot study warrant further study in a larger cohort.
Authors
- Jouni J. T. Junnila (ORCID: https://orcid.org/0000-0003-2703-0798)
- Jenni Karttunen (ORCID: https://orcid.org/0000-0002-0099-1305)
- Liisa Metsähonkala (ORCID: https://orcid.org/0009-0006-2067-256X)
- Tarja S. Jokinen (ORCID: https://orcid.org/0000-0001-6389-0109)
- Petra Kangas (ORCID: https://orcid.org/0000-0003-0297-7520)
- Tuula A. Nyman (ORCID: https://orcid.org/0000-0001-8787-5886)
Institutions
- Oslo University Hospital (NO)
- University of Helsinki (FI)
- University of Oslo (NO)
- Hospital District of Helsinki and Uusimaa (FI)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12014-025-09569-x
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto
- Universitetet i Oslo
- Norges Forskningsråd
- Helse Sør-Øst RHF