Higher Circulating Kynurenine Levels Linked to Higher Risk of Sarcopenia in Older Adults: A Cohort Study and UK Biobank Analysis
These findings extend previous experimental evidence to the clinical setting, suggesting that elevated kynurenine-driven by IDO1 activity-contributes to sarcopenia in older adults. Circulating kynurenine may serve as an exploratory biomarker candidate for identifying individuals at heightened risk for muscle deterioration, warranting further validation in future studies.
Authors
- Jong Yeob Kim (ORCID: https://orcid.org/0000-0003-4756-9440)
- Hyun Ju Yoo (ORCID: https://orcid.org/0000-0003-2617-444X)
- Ji Yeon Baek (ORCID: https://orcid.org/0000-0002-5068-5891)
- Yunju Jo (ORCID: https://orcid.org/0000-0002-6305-3324)
- Hyuk Sakong (ORCID: https://orcid.org/0000-0002-4657-4160)
- Dongryeol Ryu (ORCID: https://orcid.org/0000-0002-5335-6209)
- Sung-Jin Kim (ORCID: https://orcid.org/0000-0003-3971-0985)
- Eun-Ju Lee
- Su Jung Kim (ORCID: https://orcid.org/0000-0001-5729-2129)
- Beom-Jun Kim (ORCID: https://orcid.org/0000-0002-6977-9927)
- So Jeong Park (ORCID: https://orcid.org/0000-0003-0839-3016)
- Geundoo Jang
Institutions
- Ulsan College (KR)
- Asan Medical Center (KR)
- Gwangju Institute of Science and Technology (KR)
- University of Ulsan (KR)
- Seoul National University Dental Hospital (KR)
- Wonkwang University (KR)
Publication Details
- Journal
- Endocrinology and Metabolism
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3803/enm.2025.2586
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- Ministry of Science and ICT, South Korea
- Advanced Research Projects Agency