Nasal epithelium and blood transcriptomic signatures associations with smoking and exacerbations
<title>Extract</title> Exposure to tobacco smoke (TS) adversely affects respiratory health, and increases risk for cancer and cardiovascular disease. The major respiratory TS complication is chronic obstructive pulmonary disease (COPD), characterized by episodic exacerbations. Despite extensive COPD pathobiology investigation through gene expression studies, previous work has primarily focused on lung tissue or invasive lower airway samples [1], limiting accessibility and clinical applicability. Understanding coordinated transcriptomic signatures in nasal and blood compartments may yield novel insights into COPD pathogenesis and uncover clinically relevant biomarkers for understanding TS and exacerbation biology.
Authors
- Max A. Seibold (ORCID: https://orcid.org/0000-0002-8685-4263)
- L. Ruvuna
- Russell Paul Bowler (ORCID: https://orcid.org/0000-0003-4651-363X)
- Katherine Pratte (ORCID: https://orcid.org/0000-0003-3358-8907)
- S. Sajuthi
- Katerina Kechris (ORCID: https://orcid.org/0000-0002-3725-5459)
- Edwin K. Silverman (ORCID: https://orcid.org/0000-0002-3641-3822)
- Abhimanyu Sarkar (ORCID: https://orcid.org/0000-0002-4170-152X)
- Dawn L. DeMeo (ORCID: https://orcid.org/0000-0001-9653-0636)
- Peter J. Castaldi (ORCID: https://orcid.org/0000-0001-9920-4713)
- Craig P. Hersh (ORCID: https://orcid.org/0000-0002-1342-4334)
- Laura E. Crotty Alexander (ORCID: https://orcid.org/0000-0002-5091-2660)
- Alejandro P. Comellas (ORCID: https://orcid.org/0000-0003-1521-7520)
- Jennifer E. Dawson (ORCID: https://orcid.org/0000-0002-8387-6109)
- Igor Z Barjaktarevic
- Sunita Sharma (ORCID: https://orcid.org/0000-0002-0036-0933)
- Claire Guo
Institutions
- University of Iowa (US)
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- Colorado School of Public Health (US)
- University of California, Los Angeles (US)
- National Jewish Health (US)
- VA San Diego Healthcare System (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1183/13993003.02091-2025
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00