Effect of Ropivacain and Bupivacain on Calcium‐Related and G‐Protein Coupled Processes in PMNs: A Human In‐Vitro Study
Intracellular calcium appears to play a minimal role in the process of NETosis, while it is significantly important for neutrophil migration. Inhibition of the Gβγ subunit using gallein and PLC using U-73122 led to an earlier onset of NETosis and an increase in the maximum intracellular calcium. An additional effect of ropivacaine on the GPCR signaling pathway was not detectable.
Authors
- Richard F. Kraus (ORCID: https://orcid.org/0000-0001-5280-6530)
- Michael Gruber (ORCID: https://orcid.org/0000-0002-5509-9760)
- Sigrid Wittmann (ORCID: https://orcid.org/0000-0002-0715-3590)
- Thies Galla
Institutions
- University Hospital Regensburg (DE)
Publication Details
- Journal
- Health Science Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/hsr2.71636
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00