Evaluation of the Effect of Clobetasol Propionate on Circulating Cortisol and Growth Velocity in Children with Atopic Dermatitis: A Modelling and Simulation Study
Surface area affected by AD should be considered when assessing the risk of systemic side effects. CP can be applied up to 20% of the body surface area of a child (>1-year-old) without clinically relevant changes to circulating cortisol levels. In contrast to the systemic effects of oral corticosteroids, the short-term use of CP has no impact the GV of paediatric subjects with AD.
Authors
- Sven C. van Dijkman (ORCID: https://orcid.org/0000-0002-2799-7643)
- Janna K. Duong (ORCID: https://orcid.org/0000-0003-2347-7277)
- E. Bonifazi
- Alexandra Marta
- Adriana Ceci (ORCID: https://orcid.org/0000-0002-8778-3612)
- Oscar E. Della Pasqua (ORCID: https://orcid.org/0000-0002-6211-1430)
- G B Ong
Institutions
- GlaxoSmithKline (Australia) (AU)
- Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus (IT)
- Institute of Medical Biology (SG)
- System Simulation (United Kingdom) (GB)
- University College London (GB)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Dermatology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1159/000549781
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00