Chai-shen powder treated perimenopausal syndrome through the PI3K–Akt/cAMP signaling pathway: integrated clinical analysis, network pharmacology, microRNA and animal experiment
The clinical effective rate of CSP in this study was 87.33%. CSP may alleviate PMS by regulating hormone levels, mitigating ovarian injury and acting through multi-pathway, multi-target mechanisms.
Authors
- Shukun Yu
- Chunchao Han (ORCID: https://orcid.org/0000-0003-2843-7282)
- Yanxiao Jiang (ORCID: https://orcid.org/0009-0008-6202-2789)
- Liying Zhang (ORCID: https://orcid.org/0000-0002-9508-5144)
- Xiaoshuang Li (ORCID: https://orcid.org/0000-0001-7888-2224)
- Anran Zheng
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Climacteric
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1080/13697137.2025.2584056
- Citations
- 1
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29