Controllable site-selective C–C bond cleavage for the divergent synthesis of imidazo[1,5- <i>a</i> ]pyridine derivatives
Ethyl 3-oxo-3-phenylpropanoate reacts with phenyl(pyridin-2-yl)methanamine to afford a selective product <i>via</i> the site-selective C-C bond cleavage of ethyl 3-oxo-3-phenylpropanoate by adjusting reaction parameters, and a series of imidazo[1,5-<i>a</i>]pyridines can be effectively prepared using this method. This study enables controllable site-selectivity in both C-C bond cleavage and C-C bond formation, which may offer new insights for chemists in the C-C bond cleavage research field.
Authors
- Xinyu Song (ORCID: https://orcid.org/0000-0002-7486-9388)
- Suofu Qin (ORCID: https://orcid.org/0000-0002-3323-8846)
- Jiayi Wu (ORCID: https://orcid.org/0000-0002-4819-2190)
- Haibo Wang (ORCID: https://orcid.org/0000-0003-4809-4897)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-5480-7980)
- Wenya Dong (ORCID: https://orcid.org/0000-0001-5870-6311)
- Pingjing Xue
Institutions
- Anhui University of Science and Technology (CN)
- Anhui Science and Technology University (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra07797d
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00