Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study

Spinal hemangioblastomas (sHB) are rare vascular tumors, with distinct clinical courses between von Hippel-Lindau (VHL)-associated and sporadic cases. The MIB-1 labeling index has been proposed as a surrogate marker for tumor proliferation, but its prognostic value remains unclear in this context. In this subgroup analysis from a multicenter retrospective study, we analyzed 116 primary sHB patients with available MIB-1 indices. Patients were stratified by VHL status. Statistical comparisons included ROC analyses for local progression-free survival (PFS) prediction and Kaplan-Meier survival curves for local PFS, stratified by a MIB-1 index cut-off derived from Youden's index. The MIB-1 index was significantly lower in VHL-associated tumors compared to sporadic ones (mean 2.17% vs. 3.02%, p = 0.008). In VHL-associated sHB, a higher MIB-1 index (≥ 2%) correlated with an increased risk of local tumor progression (AUC 0.74, 95% CI 0.49-0.98), whereas this was not observed in sporadic cases (AUC 0.56, 95% CI 0.23-0.88). Kaplan-Meier analysis showed that VHL patients with MIB-1 ≥ 2% had significantly shorter PFS (p = 0.05), while no significant association was found in sporadic tumors (p = 0.87). Our findings suggest that while VHL-associated sHB exhibit lower proliferative indices overall, elevated MIB-1 labeling indices might serve as a prognostic marker of shorter local PFS in this subgroup. In contrast, MIB-1 index appears to have limited prognostic relevance in sporadic sHB. These results highlight the importance of further molecular stratification and proliferation assessment in sHB to better inform clinical decision-making.

Authors

Institutions

Publication Details

Journal
Acta Neuropathologica Communications
Published
2025-12-11
DOI
https://doi.org/10.1186/s40478-025-02202-w
Citations
1
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
0.94
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study

Peter Vajkoczy, Sandro M. Krieg, Maximilian Middelkamp, Roman Sankowski et al.
1 citations
Acta Neuropathologica Communications
Cancer, Hypoxia, and Metabolism
0.94
article

Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study

Peter Vajkoczy, Sandro M. Krieg, Maximilian Middelkamp, Roman Sankowski, Martin Vychopen, Erdem Güresir, Lukas Klein, Nicolas Neidert, Vicki M. Butenschöen, Romina Hohenhaus, Bernhard Meyer, Christine Steiert, Jan‐Helge Klingler, Obada Alhalabi, Sebastian Siller, Maria Wostrack, Sven Oliver Eicker, Marcus Czabanka, Roberto Doria-Medina, Philipp Dammann, Marc Hohenhaus, Ulrich Sure, Steven D. Chang, Tarık Tihan, Johannes Wach, Nils Ole Schmidt, Alonso Barrantes‐Freer, Alejandro N. Santos, Julia Onken, Tobias Pantel, Tomasz Czernicki, Claudius Thomé, Jürgen Beck, Przemysław Kunert, Laurèl Rauschenbach, Nikolaus Kögl, Jae‐Hyun Park, Fatma Kilinç, Alim Emre Basaran, Ahed H Kattaa
article en
1 citations

Abstract

Spinal hemangioblastomas (sHB) are rare vascular tumors, with distinct clinical courses between von Hippel-Lindau (VHL)-associated and sporadic cases. The MIB-1 labeling index has been proposed as a surrogate marker for tumor proliferation, but its prognostic value remains unclear in this context. In this subgroup analysis from a multicenter retrospective study, we analyzed 116 primary sHB patients with available MIB-1 indices. Patients were stratified by VHL status. Statistical comparisons included ROC analyses for local progression-free survival (PFS) prediction and Kaplan-Meier survival curves for local PFS, stratified by a MIB-1 index cut-off derived from Youden's index. The MIB-1 index was significantly lower in VHL-associated tumors compared to sporadic ones (mean 2.17% vs. 3.02%, p = 0.008). In VHL-associated sHB, a higher MIB-1 index (≥ 2%) correlated with an increased risk of local tumor progression (AUC 0.74, 95% CI 0.49-0.98), whereas this was not observed in sporadic cases (AUC 0.56, 95% CI 0.23-0.88). Kaplan-Meier analysis showed that VHL patients with MIB-1 ≥ 2% had significantly shorter PFS (p = 0.05), while no significant association was found in sporadic tumors (p = 0.87). Our findings suggest that while VHL-associated sHB exhibit lower proliferative indices overall, elevated MIB-1 labeling indices might serve as a prognostic marker of shorter local PFS in this subgroup. In contrast, MIB-1 index appears to have limited prognostic relevance in sporadic sHB. These results highlight the importance of further molecular stratification and proliferation assessment in sHB to better inform clinical decision-making.

Acta Neuropathologica CommunicationsVol. 14(1)
Goethe University Frankfurt (DE), Innsbruck Medical University (AT), University of Miami (US), Universität Hamburg (DE), University of Freiburg (DE), University of California, San Francisco (US), Heidelberg University (DE), Medical University of Warsaw (PL), University Medical Center Freiburg (DE), University Hospital Heidelberg (DE), TUM Klinikum (DE), Christian-Albrechts-Universität zu Kiel (DE), Humboldt-Universität zu Berlin (DE), University Medical Center Hamburg-Eppendorf (DE), Essen University Hospital (DE), University Hospital Leipzig (DE), University Hospital Frankfurt (DE), Klinikum Passau (DE), Neurological Surgery (US), University of Regensburg (DE), Technical University of Munich (DE), Freie Universität Berlin (DE), Charité - Universitätsmedizin Berlin (DE), Leipzig University (DE), Stanford University (US)
Openalex Percentile: Top 18%
Cancer, Hypoxia, and Metabolism
0.94
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.