Intratracheal administration of mesenchymal stem cells ameliorates hyperoxia-induced bronchopulmonary dysplasia by inhibiting NLRP3 inflammasome activation: the critical role of Aldh1a2
Aldh1a2 was significantly differentially expressed in hyperoxic lung injury, with hyperoxia suppressing its expression and UCMSC treatment promoting its upregulation. Aldh1a2 mitigates lung inflammation and oxidative stress by inhibiting NLRP3 inflammasome activation.
Authors
- Na Dong (ORCID: https://orcid.org/0000-0002-0129-5934)
- Linghong Liu (ORCID: https://orcid.org/0000-0003-0212-2573)
- Tianqing Xin
- Xiuli Ju (ORCID: https://orcid.org/0000-0001-5464-3106)
- Qing Shi (ORCID: https://orcid.org/0000-0002-8123-2465)
- Dong Li (ORCID: https://orcid.org/0000-0001-7228-8355)
- Xuejing Xu
Institutions
- Second Hospital of Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s13287-025-04851-z
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52