Spatial transcriptomics defines the molecular progression, invasion and immune landscape of IPMN and IPMN-derived pancreatic cancer
This study provides a spatially resolved molecular map of IPMN progression, delineating key transcriptomic and immune signatures. These findings advance the understanding of IPMN biology and highlight potential biomarkers for risk stratification and therapeutic strategies.
Authors
- Decheng Jiang
- Shengwei Mo (ORCID: https://orcid.org/0000-0001-9401-3141)
- Ming Cui (ORCID: https://orcid.org/0000-0001-8770-4585)
- Christopher L. Wolfgang (ORCID: https://orcid.org/0009-0000-5817-6146)
- Joseph R. Habib (ORCID: https://orcid.org/0000-0003-3445-2278)
- Wenwen Diao (ORCID: https://orcid.org/0000-0002-4443-309X)
- Xiaoyan Chang
- Ammar A. Javed (ORCID: https://orcid.org/0000-0002-5463-5250)
- Ya Hu (ORCID: https://orcid.org/0000-0003-2813-9947)
- Jialu Bai (ORCID: https://orcid.org/0009-0007-7625-5471)
- Ruiling Xiao (ORCID: https://orcid.org/0009-0000-6410-9847)
- Tianqi Chen (ORCID: https://orcid.org/0000-0002-8762-9682)
- Yu-pei Zhao
- Sen Yang (ORCID: https://orcid.org/0000-0003-3125-6626)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- NYU Langone Health (US)
Publication Details
- Journal
- Gut
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1136/gutjnl-2025-336117
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05