Renal clear cell carcinoma with bilateral parotid and orbital metastases – case report

Metastatic involvement of the oral and maxillofacial region is an uncommon clinical event. These secondary lesions may develop in several anatomical locations, most frequently within the parotid glands or orbital structures. While many primary tumors that spread to these regions arise from neighboring sites such as the scalp, face, oral cavity, or pharynx, distant subclavicular malignancies can also give rise to metastases in these areas. Among such tumors, renal cell carcinoma (RCC) is the third most frequent source of metastasis to the oral and maxillofacial region. Nevertheless, reports of RCC spreading to the parotid or orbital regions remain exceptionally rare. We present a distinctive clinical case of a 54-year-old man with clear cell RCC that, during its progression, produced simultaneous metastases to both parotid glands and to the orbital region - a combination that, to our knowledge, has not been previously documented in the medical literature.