Targeted virome deep sequencing reveals frequent herpesvirus detection in intestinal biopsies of inflammatory bowel disease patients
Herpesviruses are rarely detected in healthy intestinal viromes and are generally considered absent, whereas their frequent presence in IBD biopsies suggests possible pathological relevance. Our findings highlight the value of metagenomic sequencing in characterizing the intestinal virome to assess the diagnostic or prognostic value of viral biomarkers in IBD.
Authors
- Jorge Andres Cardona Vasquez (ORCID: https://orcid.org/0000-0001-5771-837X)
- Vanessa Recio (ORCID: https://orcid.org/0009-0006-6106-9230)
- Juan Pedro M. Camacho (ORCID: https://orcid.org/0000-0002-2507-9814)
- David Tarragó (ORCID: https://orcid.org/0000-0002-1298-3089)
- E. García-Ruiz (ORCID: https://orcid.org/0000-0003-2640-8496)
- Pedro Doncel
Institutions
- Instituto de Salud Carlos III (ES)
- Institut Botànic de Barcelona (ES)
- Centro Nacional de Microbiologia (ES)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1371/journal.pone.0337322
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00