MOF MIL-53(Al) catalyzed hydroacylation of azodicarboxylates: sustainable catalyst for heterogeneous acylhydrazide synthesis
This study reports one of the few examples of acylhydrazide synthesis catalyzed by the metal-organic framework (MOF) MIL-53(Al) <i>via</i> the aldehyde C(sp<sup>2</sup>)-H hydrazidation reaction. The material exhibited high catalytic performance, displaying a broad substrate scope and affording yields of up to 97%. The catalyst retained its structural integrity and activity for at least four consecutive cycles, with no significant metal leaching. Notably, MIL-53(Al) was synthesized from waste-derived materials and thoroughly characterized to confirm its crystallinity, structural integrity, and porosity - features essential to its catalytic function. This work demonstrates the potential of upcycled MIL-53(Al) as a stable, sustainable, and low-cost heterogeneous catalyst for the synthesis of valuable acylhydrazides, offering an attractive alternative to conventional systems that rely on toxic metal promoters.
Authors
- Rajender S. Varma (ORCID: https://orcid.org/0000-0001-9731-6228)
- Ernesto C. Pereira (ORCID: https://orcid.org/0000-0003-1058-302X)
- Márcio W. Paixão (ORCID: https://orcid.org/0000-0002-0421-2831)
- Kelvin C. Araújo (ORCID: https://orcid.org/0009-0008-9388-551X)
- Lucas Marchini (ORCID: https://orcid.org/0000-0002-6349-5181)
- Reynier Báez
- José A. C. Delgado (ORCID: https://orcid.org/0000-0002-5994-7384)
- Stefano De Martin
- Felipe Verdugo (ORCID: https://orcid.org/0000-0002-2466-5643)
- Claudio A. Jiménez (ORCID: https://orcid.org/0000-0002-2622-8308)
Institutions
- University of Concepción (CL)
- Universidade Federal de São Carlos (BR)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra07909h
- Primary Topic
- Metal-Organic Frameworks: Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Instituto Nacional de Ciência e Tecnologia de Catálise em Sistemas Moleculares e Nanoestruturados
- Agencia Nacional de Investigación y Desarrollo