Grape seed proanthocyanidin extract inhibits ferroptosis by activating Nrf2/HO-1 and protects against diabetic kidney disease
GSPE treatment reduced ferroptosis in DKD by modulating the Nrf2/HO-1. In conclusion, our results underscore the significance of ferroptosis in DKD and present new perspectives on the protective effects of GSPE in this condition.
Authors
- Haowei Zhang (ORCID: https://orcid.org/0000-0002-6607-5166)
- Hao Wang (ORCID: https://orcid.org/0000-0003-0612-295X)
- Bing Chang (ORCID: https://orcid.org/0000-0003-1965-5827)
- Yanhua Ding (ORCID: https://orcid.org/0009-0005-4648-4797)
- Haiyan Li (ORCID: https://orcid.org/0000-0002-5541-3035)
- Tingting Li (ORCID: https://orcid.org/0000-0001-5814-0514)
- Heng Lu (ORCID: https://orcid.org/0000-0001-9775-7824)
- Ruirui Yang (ORCID: https://orcid.org/0000-0002-7480-5077)
Institutions
- Shihezi University (CN)
- Xinjiang Medical University (CN)
- University of Victoria (CA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1371/journal.pone.0336472
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xinjiang Medical University