RUNX1 is expressed in a subpopulation of dermal fibroblasts and is associated with disease severity of systemic sclerosis
This study is the first to demonstrate a potential role for RUNX1 in the pathogenesis of SSc dermal fibrosis. RUNX1 is associated with more severe SSc fibrosis and is associated with a subpopulation of dermal fibroblasts implicated in fibrosis.
Authors
- Poulami Dey (ORCID: https://orcid.org/0000-0001-7589-0034)
- Ted Abel (ORCID: https://orcid.org/0000-0003-2423-4592)
- Helen Jarnagin
- Madeline J Morrisson
- Sasha Shenk
- Olesya Plazyo (ORCID: https://orcid.org/0000-0002-6859-7590)
- Mrinal K. Sarkar (ORCID: https://orcid.org/0000-0001-8505-4259)
- Patricia Ann Pioli (ORCID: https://orcid.org/0000-0001-6896-7259)
- Monique Hinchcliff (ORCID: https://orcid.org/0000-0002-8652-9890)
- Lam C. Tsoi (ORCID: https://orcid.org/0000-0003-1627-5722)
- Johann Eli Gudjonsson (ORCID: https://orcid.org/0000-0002-0080-0812)
- Dillon Popovich (ORCID: https://orcid.org/0000-0002-3015-4030)
- Diana M. Toledo (ORCID: https://orcid.org/0000-0002-7501-8286)
- Rezvan Parvizi (ORCID: https://orcid.org/0000-0001-8650-1225)
- Anthony Coon
- Tammara Wood (ORCID: https://orcid.org/0000-0002-4370-1398)
- Michael L. Whitfield (ORCID: https://orcid.org/0000-0002-0862-6003)
- Zhiyun Gong
- Dinesh Khanna
- Pei-Suen Tsou
- Jonathan A. Garlick (ORCID: https://orcid.org/0000-0003-0607-0272)
- Jake M Erba
Institutions
- Dartmouth College (US)
- Tufts University (US)
- University of Michigan (US)
- Yale University (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.ard.2025.10.033
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Dartmouth College
- National Scleroderma Foundation
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases