Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration
The conjugation of RXFP1-binding peptides to glycine-functionalised biodegradable SPIONs allowed for their circumnavigation of the gut, and prolonged activity as orally administered therapies. These findings have significant ramifications for the oral administration of peptide therapies in general.
Authors
- Mohammed Akhter Hossain (ORCID: https://orcid.org/0000-0002-9961-0006)
- Chrishan S. Samuel (ORCID: https://orcid.org/0000-0003-0295-4214)
- Dorota Ferens
- Cordelia Selomulya (ORCID: https://orcid.org/0000-0001-5506-0308)
- Ekaterina Salimova
- Amlan Chakraborty (ORCID: https://orcid.org/0000-0002-2917-6486)
- Wei Chen (ORCID: https://orcid.org/0000-0002-4040-6721)
- Chao Wang (ORCID: https://orcid.org/0000-0002-5898-9283)
- Yifang Li (ORCID: https://orcid.org/0000-0002-1884-2754)
- Deidree V N Somanader-Livera
Institutions
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Discovery Institute (US)
- University of Manchester (GB)
- UNSW Sydney (AU)
- Monash University (AU)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s12929-025-01198-8
- Citations
- 1
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- Monash University
- Medical Research Council
- Monash Biomedicine Discovery Institute, Monash University