Administration of antivirals, IL-6 inhibitors, monoclonal neutralizing antibodies and systemic corticosteroids in acute SARS-CoV-2 infection do not reduce the subsequent burden of Long-COVID symptoms
Some drug classes showed a protective effect that was however not confirmed in multivariable analyses, underlining the importance of adjusting for a comprehensive number of covariates. Clinicians should consider the possibility that systemic corticosteroids and IL-6 inhibitors administered during acute COVID-19 may prolong the persistence of particular symptoms.
Authors
- Emanuela Barisione (ORCID: https://orcid.org/0000-0001-5365-134X)
- K Loso
- Gianfranco Parati (ORCID: https://orcid.org/0000-0001-9402-7439)
- Donato Lacedonia (ORCID: https://orcid.org/0000-0003-0429-7967)
- Marco Floridia (ORCID: https://orcid.org/0000-0003-3971-0141)
- Guido Vagheggini (ORCID: https://orcid.org/0000-0001-6733-2809)
- Stefano Figliozzi (ORCID: https://orcid.org/0000-0003-2991-1548)
- Matteo Tosato (ORCID: https://orcid.org/0000-0001-5750-9746)
- Maria Rosa Ciardi (ORCID: https://orcid.org/0000-0002-0894-6496)
- Domenico Maurizio Toraldo (ORCID: https://orcid.org/0000-0003-0023-0212)
- Piergiuseppe Agostoni (ORCID: https://orcid.org/0000-0002-8345-6382)
- Paola Gnerre (ORCID: https://orcid.org/0000-0002-1397-6059)
- Maria Antonietta Di Rosolini (ORCID: https://orcid.org/0000-0003-4905-5072)
- P. Andreozzi (ORCID: https://orcid.org/0000-0003-0369-8750)
- Paolo Bonfanti (ORCID: https://orcid.org/0000-0001-7289-8823)
- Giuseppe Pio Martino (ORCID: https://orcid.org/0000-0002-4906-0472)
- Silvia Zucco
- Patrizia Rovere-Querini
- Aldo Lo Forte
- Paolo Palange (ORCID: https://orcid.org/0000-0002-5824-6455)
- Liliana Elena Weimer (ORCID: https://orcid.org/0000-0002-1554-3150)
- Graziano Onder
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Foggia (IT)
- Humanitas University (IT)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Istituto Superiore di Sanità (IT)
- Policlinico Umberto I (IT)
- Trinity Hospital of Augusta (US)
- Centro Cardiologico Monzino (IT)
- ASL Roma (IT)
- University of Ragusa (IT)
- Nuovo Ospedale San Giovanni di Dio (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Ospedale Amedeo di Savoia (IT)
- Alessandro Manzoni Hospital (IT)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Ospedale Policlinico San Martino (IT)
- Azienda Sanitaria Locale N. 2 Savonese (IT)
- Ospedale Vito Fazzi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Usl Toscana Centro (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Milano-Bicocca (IT)
- International Flame Research Foundation (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Infezioni in Medicina
- Published
- 2025-12-01
- DOI
- https://doi.org/10.53854/liim-3304-4
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Istituto Superiore di Sanità