Circulating monocytes from systemic sclerosis patients with progressive interstitial lung disease preferentially express M2 phenotype markers: in vitro and ex vivo study
Cultured MDMs from circulating monocytes in SSc pts with prog-ILD show markedly increased profibrotic biomarkers and mediator expression, indicating an enhanced fibrotic phenotype compared to non-prog and no-ILD SSc pts.
Authors
- Rosanna Campitiello (ORCID: https://orcid.org/0009-0009-1093-1611)
- Emanuele Gotelli (ORCID: https://orcid.org/0000-0002-4732-0306)
- Stefano Soldano (ORCID: https://orcid.org/0000-0001-8796-6032)
- Vanessa Smith (ORCID: https://orcid.org/0000-0001-6271-7945)
- Alberto Sulli (ORCID: https://orcid.org/0000-0003-3674-4880)
- Maurizio Cutolo (ORCID: https://orcid.org/0000-0002-5396-0932)
- Paola Montagna (ORCID: https://orcid.org/0000-0002-0595-1484)
- Elvis Hysa (ORCID: https://orcid.org/0000-0002-6970-0983)
- Sabrina Paolino (ORCID: https://orcid.org/0000-0001-9269-5089)
- T. Vojinovic (ORCID: https://orcid.org/0000-0003-1720-1151)
- A. Cere (ORCID: https://orcid.org/0000-0001-7163-1051)
- Carmen Pizzorni (ORCID: https://orcid.org/0000-0001-5125-0200)
Institutions
- Ghent University Hospital (BE)
- Ospedale Policlinico San Martino (IT)
- Flemish Institute for Technological Research (BE)
- University of Genoa (IT)
Publication Details
- Journal
- RMD Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-006135
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering