Prognostic factors of oral squamous cell carcinoma: a five-year retrospective study in Cluj-Napoca, Romania
The five-year survival rate of 50% reflects both aggressive tumor biology and systemic barriers to care. Clinical stage remains the strongest prognostic factor, but tumor site and histological features, including perineural and lymphatic invasion, significantly influence outcomes even in early disease. Improved long-term survival requires earlier diagnosis, refined prognostic assessment, and multimodal therapy tailored to tumor behavior, alongside better patient follow-up strategies.
Authors
- Răzvan Marius Vicaş
- Mădălina Anca Moldovan (ORCID: https://orcid.org/0009-0009-0239-8044)
- Cristian Niky Cumpătă (ORCID: https://orcid.org/0000-0001-5414-0031)
- Rareș Călin Roman (ORCID: https://orcid.org/0000-0003-0620-2845)
- Dragos A. Țermure (ORCID: https://orcid.org/0000-0003-4796-7473)
- A.I. Precup (ORCID: https://orcid.org/0000-0002-2915-3743)
- Bogdan Andrei Bumbu (ORCID: https://orcid.org/0000-0003-4645-9047)
- Cristina Maria Neghină
Institutions
- University of Oradea (RO)
Publication Details
- Journal
- Romanian Journal of Morphology and Embryology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.47162/rjme.66.3.15
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitatea de Medicină şi Farmacie Iuliu Haţieganu Cluj-Napoca