Effectiveness of 2023–2024 Coronavirus Disease 2019 (COVID-19) Vaccines in Pregnant Women
Pregnant women are at higher risk of severe coronavirus disease 2019 (COVID-19) compared with nonpregnant women of reproductive age. During 2023-2024, the Centers for Disease Control and Prevention recommended COVID-19 vaccination for everyone aged 6 months or older, including pregnant women. Using a test-negative design, we assessed the effectiveness of 2023-2024 COVID-19 vaccines against COVID-19-associated emergency department (ED) and urgent care setting encounters among pregnant women aged 18-45 years presenting for care with COVID-19 symptoms from September 2023 to August 2024. Vaccine effectiveness against COVID-19-associated ED and urgent care encounters of one 2023-2024 COVID-19 vaccine dose was 58% (95% CI, 24-77%) among pregnant women and 37% (95% CI, 29-44%) among nonpregnant women of the same age. The 2023-2024 COVID-19 vaccines were associated with a decrease in COVID-19-associated ED and urgent care encounters among pregnant women and nonpregnant women of reproductive age.
Authors
- Christian M. Rogerson (ORCID: https://orcid.org/0000-0003-1306-8867)
- William F. Fadel (ORCID: https://orcid.org/0000-0002-0292-6734)
- Toan C. Ong (ORCID: https://orcid.org/0000-0001-6787-1407)
- Allison L. Naleway (ORCID: https://orcid.org/0000-0001-5747-4643)
- Catia Chávez
- Pradeep Koppolu (ORCID: https://orcid.org/0000-0001-8226-6926)
- David Mayer (ORCID: https://orcid.org/0000-0002-6056-9771)
- Ousseny Zerbo (ORCID: https://orcid.org/0000-0002-8380-6215)
- Brian E. Dixon (ORCID: https://orcid.org/0000-0002-1121-0607)
- Allison Avrich Ciesla (ORCID: https://orcid.org/0000-0001-8739-1005)
- Ruth Link‐Gelles (ORCID: https://orcid.org/0000-0002-9617-806X)
- Angela M. Cheung (ORCID: https://orcid.org/0000-0001-8332-0744)
- Lawrence Reichle
- Michelle A. Barron (ORCID: https://orcid.org/0000-0002-8217-7410)
- Nicola P. Klein (ORCID: https://orcid.org/0000-0003-1777-4814)
- Julius Timbol
- Malini B. DeSilva (ORCID: https://orcid.org/0000-0003-3705-1672)
- John Hansen (ORCID: https://orcid.org/0000-0001-7891-2673)
- Sarah W. Ball (ORCID: https://orcid.org/0000-0002-0903-8107)
- Shaun J. Grannis (ORCID: https://orcid.org/0000-0002-8093-6639)
- Stephanie A. Irving (ORCID: https://orcid.org/0000-0001-7437-6797)
- Victoria Lazariu
- Julie Arndorfer
- Daniel Bride (ORCID: https://orcid.org/0000-0002-7950-1267)
- Janet A. Watts
- Karthik V. Natarajan (ORCID: https://orcid.org/0000-0002-9066-9431)
- Kristin Dascomb (ORCID: https://orcid.org/0000-0002-7422-060X)
- Amanda B. Payne (ORCID: https://orcid.org/0000-0003-1027-7639)
- Gabriela Vazquez‐Benitez (ORCID: https://orcid.org/0000-0002-6226-3207)
- Tamara Sheffield
- Yan Zhuang (ORCID: https://orcid.org/0000-0003-1756-0277)
- Bruce Fireman
- Joshua Van Otterloo
Institutions
- Kaiser Permanente Center for Health Research (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Obstetrics and Gynecology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1097/aog.0000000000006145
- Primary Topic
- COVID-19 Impact on Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00