Plasma placental growth factor as a susceptibility biomarker for longitudinal cognitive change
Higher plasma placental growth factor (PlGF) concentrations relate to greater baseline white matter injury. Elevated baseline plasma PlGF associates with steeper cognitive decline over time. PlGF may represent an upstream biomarker of endothelial-related cognitive decline.
Authors
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-1308-646X)
- Anna M. VandeBunte (ORCID: https://orcid.org/0000-0002-5167-3358)
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Rowan Saloner (ORCID: https://orcid.org/0000-0002-1351-6183)
- Valentina E. Diaz
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Claire J. Cadwallader (ORCID: https://orcid.org/0000-0003-3449-3803)
- Jason D. Hinman (ORCID: https://orcid.org/0000-0002-0872-5044)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-1206-404X)
- Kaitlin B. Casaletto
- Savannah R. Hallgarth
- Molly Olzinski
Institutions
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70936
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Larry L. Hillblom Foundation
- American Brain Foundation
- National Institutes of Health
- National Institute on Aging