A Natural Composite Extract Restores Skin Barrier Function by Modulating Inflammatory, Hydration, and Redox Pathways
Across all endpoints, pediatric keratinocytes exhibited more pronounced responses, suggesting age-dependent differences in sensitivity. These in vitro findings support PLCP's multifunctional role at anti-inflammatory, anti-pruritic, moisturizing, and antioxidant and highlight its promise as a safe, plant-based alternative for managing pediatric skin disorders.
Authors
- Nguyen Ngan Giang (ORCID: https://orcid.org/0000-0002-4049-2412)
- Woon Ha Kim (ORCID: https://orcid.org/0009-0004-5083-3884)
- Keonwoo Choi (ORCID: https://orcid.org/0000-0002-4670-9635)
- Chan Yeong Heo (ORCID: https://orcid.org/0000-0001-9003-7365)
- Linh Thi Thuy Le (ORCID: https://orcid.org/0000-0002-7193-9053)
- Yongxun Jin (ORCID: https://orcid.org/0009-0008-8672-7740)
- Pham Ngoc Chien (ORCID: https://orcid.org/0000-0003-1419-3766)
- Caijun Jin (ORCID: https://orcid.org/0000-0003-2982-943X)
- Xinrui Zhang (ORCID: https://orcid.org/0000-0002-5615-6341)
- Yong Hyun Lee (ORCID: https://orcid.org/0009-0002-1447-2079)
- H. Kim (ORCID: https://orcid.org/0000-0002-8172-7417)
- Jae Hee Choi (ORCID: https://orcid.org/0009-0009-8660-0544)
- Youn Ju Jeong (ORCID: https://orcid.org/0009-0002-7308-9627)
Institutions
- Seoul National University (KR)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Hai phong University Of Medicine and Pharmacy (VN)
- New Generation University College (ET)
- Seoul National University Bundang Hospital (KR)
- Korean Academy of Science and Technology (KR)
- Hai Phong University (VN)
- Zero to Three (US)
- Skin Research Center (FR)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/jocd.70613
- Primary Topic
- Neonatal skin health care
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Health Industry Development Institute