Demyelination-related pain: role of lysophosphatidic acid in satellite glial cell–neuron crosstalk
Our study demonstrates that LPA-LPA1R signaling in SGCs drives A-fiber demyelination-induced neuropathic pain by promoting Cx43-mediated SGC-neuron crosstalk and cytokine release. Targeting this pathway may represent a promising strategy to alleviate demyelination-associated chronic pain.
Authors
- Ying Jia (ORCID: https://orcid.org/0000-0001-6195-0526)
- Wei Yang (ORCID: https://orcid.org/0000-0001-8162-033X)
- Yujia Huang (ORCID: https://orcid.org/0000-0001-7947-1582)
- Jiantao Qu (ORCID: https://orcid.org/0009-0004-1269-852X)
- Yun Guan (ORCID: https://orcid.org/0000-0003-1321-6655)
- Shupei Qiao (ORCID: https://orcid.org/0000-0002-4555-7190)
- Siyang Zheng
- Xiaodan Song
- Feng‐Quan Zhou (ORCID: https://orcid.org/0000-0002-1525-9969)
- Xinzhong Dong (ORCID: https://orcid.org/0000-0002-9750-7718)
- Menachem Hanani (ORCID: https://orcid.org/0000-0002-6716-1453)
- Qiong Sun (ORCID: https://orcid.org/0000-0002-2784-8066)
- Tuo Shao (ORCID: https://orcid.org/0000-0001-7144-9823)
- Yujie Yang (ORCID: https://orcid.org/0000-0002-7202-3776)
- Zhiyong Chen (ORCID: https://orcid.org/0000-0003-0475-3491)
- Yuchen Wang (ORCID: https://orcid.org/0000-0002-5862-8322)
- Hui Zhu (ORCID: https://orcid.org/0000-0001-8988-9245)
- Xu Guo (ORCID: https://orcid.org/0009-0004-1258-8232)
Institutions
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Harbin Medical University (CN)
- Hebrew University of Jerusalem (IL)
- Johns Hopkins Medicine (US)
- Sir Run Run Shaw Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s12967-025-07568-y
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33