APOE isoform‐associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity
Conformational and bioactivity distinctions of tau oligomers have not yet been investigated across the APOE isoforms (ε2, ε3, ε4). Tau oligomers differ in conformational properties across the APOE isoforms. APOE ε4-relevant tau oligomers strongly impair synaptic plasticity and demonstrate high tau seeding activity. APOE ε4-relevant tau oligomers exist as a particularly toxic species, making them an ideal target for tau-based AD therapies.
Authors
- Naomi Moreno (ORCID: https://orcid.org/0000-0003-0482-1394)
- Rakez Kayed (ORCID: https://orcid.org/0000-0001-6216-8640)
- Md. Anzarul Haque (ORCID: https://orcid.org/0000-0002-4603-6565)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Nemil Bhatt (ORCID: https://orcid.org/0000-0001-5017-7312)
- Leiana Fung (ORCID: https://orcid.org/0000-0002-0874-1597)
- Yingxin Zhao (ORCID: https://orcid.org/0000-0002-8872-5860)
- Agenor Limón (ORCID: https://orcid.org/0000-0002-6613-770X)
- Nikita Shchankin
- Nicha Puangmalai (ORCID: https://orcid.org/0000-0002-1138-237X)
Institutions
- University of Washington (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70965
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00