PP2A methylesterase, PME‐1, and PP2A methyltransferase, LCMT‐1, control sensitivity to impairments caused by injury‐related oligomeric tau
LCMT-1 and PME-1 overexpression alters sensitivity to oligomeric tau-induced impairments. Blast-induced traumatic brain injury increases the propensity of tau to oligomerize. Pathogenic tau-induced cognitive impairments were dependent on its oligomeric form.
Authors
- Russell E. Nicholls (ORCID: https://orcid.org/0000-0002-8964-574X)
- Antonio Masone (ORCID: https://orcid.org/0000-0001-8357-5931)
- Edward W. Vogel
- Barclay Morrison (ORCID: https://orcid.org/0000-0001-7676-0864)
- Nicholas M. Kanaan (ORCID: https://orcid.org/0000-0002-4362-2593)
- Kesava Asam (ORCID: https://orcid.org/0000-0002-6247-9905)
- Mauro Fà (ORCID: https://orcid.org/0000-0002-8348-0382)
- Ottavio Arancio (ORCID: https://orcid.org/0000-0001-6335-164X)
- Erica Acquarone (ORCID: https://orcid.org/0000-0002-3266-8115)
- Anna Staniszewski
- Liwei Shen
- Shenghui Liang (ORCID: https://orcid.org/0000-0002-3698-3390)
- Christopher D. Hue
- Sowmya N. Sundaresh
- Madhumathi Gnanaprakash
- Hanna L. Berman (ORCID: https://orcid.org/0000-0002-8616-8167)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-3249-0935)
- Zafar Gill
Institutions
- Pace University (US)
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70947
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- U.S. Department of Defense