Graveoumarins A–C: chiral resolution, absolute configuration, and anticoagulant/anti-inflammatory activities of 3′-methyl-3′-butenyl coumarins from <i>ruta graveolens</i> L
This study successfully characterized the chirality and determined the absolute configurations of specific 3'-methyl-3'-butenylcoumarins from <i>R. graveolens</i>, including the discovery of three new compounds. While most isolated compounds lacked significant anticoagulant or anti-inflammatory activity in the tested models, racemic (±)-<b>3</b> showed moderate anti-inflammatory potential by inhibiting NO production. These findings provide new insights for the future development and utilization of coumarins from <i>R. graveolens</i>.
Authors
- Yueping Jiang (ORCID: https://orcid.org/0000-0002-9603-3581)
- Hao Huang (ORCID: https://orcid.org/0000-0002-5570-6145)
- Jian Yin (ORCID: https://orcid.org/0000-0002-8102-0702)
- Lingfei Tong
- Feng Xu (ORCID: https://orcid.org/0000-0001-9985-6527)
- Yuxin Wang (ORCID: https://orcid.org/0000-0003-0291-495X)
- Xiongjun Hou
- Zhihao Wu (ORCID: https://orcid.org/0000-0003-1118-5146)
- Xiaolin Liao
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Central South University (CN)
- Hunan University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Hunan Mawangdui Hospital (CN)
- Jiangxi Provincial People's Hospital (CN)
- Gannan Medical University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1080/13880209.2025.2599599
- Primary Topic
- Plant chemical constituents analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00