Association between triglyceride-glucose index combined with a body shape index and atherosclerotic cardiovascular disease risk varies by glycemic status: insights from the UK Biobank
In the normoglycemia subgroup, the association between the TyG-ABSI and ASCVD was nonlinear. Moreover, the TyG-ABSI was linearly associated with an increased risk of ASCVD in the diabetes subgroup but not in the dysglycemia subgroup. The predictive value of the TyG-ABSI across different glycemic statuses provides new evidence for medical practice. Furthermore, the TyG-ABSI may serve as a useful tool for identifying high-risk individuals within the seemingly low-risk normoglycemic population and for further risk identification among diabetic patients.
Authors
- Zhixin Tan (ORCID: https://orcid.org/0000-0002-9764-0682)
- Aijun Chen (ORCID: https://orcid.org/0000-0002-2076-0555)
- Jin Chen (ORCID: https://orcid.org/0000-0002-4373-1618)
- Jingbo Zhang (ORCID: https://orcid.org/0000-0002-6724-8161)
- Lifu Sun
- Xinyi Shao
- Yidian Fu
- Genlong Bai (ORCID: https://orcid.org/0000-0002-3256-9504)
Institutions
- Hebei General Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
- The University of Osaka (JP)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s12933-025-03021-y
- Citations
- 3
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 3.88