The impact of metformin use on survival outcomes in colorectal cancer: A systematic review and meta-analysis
Metformin use is reported to be associated with favorable prognostic outcomes in individuals with CRC, particularly among those with type 2 diabetes. However, its role in disease recurrence remains uncertain. Further randomized controlled investigations are required to validate these results and to establish their relevance in non-diabetic populations.
Authors
- Mahmoud Shirali (ORCID: https://orcid.org/0000-0001-9893-831X)
- Niloufar Shabani
- Mohammad Rahmanian (ORCID: https://orcid.org/0000-0002-0401-2637)
- Soudeh Ghafouri‐Fard (ORCID: https://orcid.org/0000-0002-0223-499X)
- Nima Barazandeh
- Fatemeh Khosravi (ORCID: https://orcid.org/0000-0001-5075-7755)
- M Mesri
- Iman Elahi Vahed
- Mehraban Amirhosseini
- Mahdi Bamdad
- Amirmohammad Jabbarpour
Institutions
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Cancer Treatment and Research Communications
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1016/j.ctarc.2025.101073
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00