Sex-related upregulation of bone morphogenetic protein signaling inhibits adult neurogenesis in APPNL−G−F alzheimer’s disease model mice
Our findings reveal a sex-dependent impairment of neurogenesis in APP<sup>NL-G-F</sup> mice driven by BMP signaling. Blocking BMP signaling enhances adult neural stem cell proliferation in female APP<sup>NL-G-F</sup> mice, providing a potential therapeutic target for AD.
Authors
- Takaomi C. Saido (ORCID: https://orcid.org/0000-0003-1970-6903)
- Xingyu Su
- Hiroki Maeda
- R Takayanagi
- Toshio Ohshima
Institutions
- Waseda University (JP)
- RIKEN Center for Brain Science (JP)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1186/s13293-025-00799-0
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science