Exploring Persistent Apical Periodontitis in Humans: Integrative Genetic, Histological and Microbiological Perspectives for Translational Research
This exploratory study indicates that genetic polymorphisms can modulate gene expression and protein activity in PAP, shaping the host's inflammatory and reparative response. These findings highlight their potential as biomarkers and establish a basis for future translational studies.
Authors
- Rafael Verardino de Camargo (ORCID: https://orcid.org/0000-0002-6546-9980)
- Jardel Francisco Mazzi‐Chaves (ORCID: https://orcid.org/0000-0002-9889-1790)
- Raquel Assed Bezerra da Silva (ORCID: https://orcid.org/0000-0002-0230-1347)
- Yara Teresinha Corrêa Silva‐Sousa (ORCID: https://orcid.org/0000-0002-7671-1656)
- Érika Calvano Küchler (ORCID: https://orcid.org/0000-0001-5351-2526)
- Manoel Damião Sousa‐Neto (ORCID: https://orcid.org/0000-0002-7696-7600)
- Alice Corrêa Silva‐Sousa (ORCID: https://orcid.org/0000-0002-9931-0935)
- Fabiane Carneiro Lopes‐Olhê (ORCID: https://orcid.org/0000-0003-4375-3371)
- André Pitondo‐Silva (ORCID: https://orcid.org/0000-0003-0098-9667)
- Francisco Wanderley Garcia Paula‐Silva (ORCID: https://orcid.org/0000-0001-8559-532X)
- Igor Bassi Ferreira Petean (ORCID: https://orcid.org/0000-0002-2704-5730)
- Fernanda Gonçalves Basso (ORCID: https://orcid.org/0000-0002-7170-2371)
- Léa Assed Bezerra da Silva (ORCID: https://orcid.org/0000-0001-7118-6859)
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- University Hospital Bonn (DE)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1111/iej.70070
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior