Cardioprotective mechanism of ω-3 fatty acid icosapent ethyl (IPE) in cardiomyocytes: role in high glucose and shear stress-induced mechano-transduction dysregulation
Our results demonstrate a cardioprotective role of IPE through modulation of hyperglycaemia-induced mechano-transduction dysregulation, inflammation, and oxidative stress. Additionally, our results on a shear stress model showing that IPE restores upstream regulators of YAP/TAZ and reduces disturbed flow-induced activation of pro-inflammatory pathways, suggest that IPE may exert a therapeutic effect on cardiovascular disorders associated with disturbed blood flow and hemodynamic stress.
Authors
- Michelangela Barbieri (ORCID: https://orcid.org/0000-0002-9223-5792)
- Annalisa Capuano (ORCID: https://orcid.org/0000-0002-8653-2408)
- Giuseppe Signoriello (ORCID: https://orcid.org/0000-0002-6609-2708)
- Giovanni Tortorella (ORCID: https://orcid.org/0009-0000-1284-8824)
- Ada Pesapane (ORCID: https://orcid.org/0009-0002-5541-8255)
- Rosaria Anna Fontanella (ORCID: https://orcid.org/0009-0008-5225-3364)
- Ludovica Vittoria Marfella
- Asad Zia (ORCID: https://orcid.org/0000-0002-3212-9170)
- Nunzia Balzano
- Lucia Scisciola (ORCID: https://orcid.org/0000-0003-3636-4298)
- Giuseppe Paolisso (ORCID: https://orcid.org/0000-0002-2137-455X)
- Celestino Sardu (ORCID: https://orcid.org/0000-0001-5099-3790)
- Maryam Arshad
- A. Palazzo
- Manuela Giovanna Basilicata
- Zeeshan Ulfat
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Regione Campania (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s12933-025-03033-8
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00