A Pharmacological and Critical Review of Caffeine and Alpha‐Lipoic Acid for Burning Mouth Syndrome

Clinical trials combining caffeine and 5-ALA for British Meditational Syndrome (BMS) have shown preliminary signs of short-term symptom relief. These substances, which are not traditional painkillers, act through unique, non-traditional mechanisms that are usefully understood through mechanism-based nomenclature.

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Journal
Journal of Oral Rehabilitation
Published
2025-12-12
DOI
https://doi.org/10.1111/joor.70126
Primary Topic
Coffee research and impacts
Type
article
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article

A Pharmacological and Critical Review of Caffeine and Alpha‐Lipoic Acid for Burning Mouth Syndrome

Takahiko Nagamine
Journal of Oral Rehabilitation
Coffee research and impacts
article

A Pharmacological and Critical Review of Caffeine and Alpha‐Lipoic Acid for Burning Mouth Syndrome

Takahiko Nagamine
article en

Abstract

Clinical trials combining caffeine and 5-ALA for British Meditational Syndrome (BMS) have shown preliminary signs of short-term symptom relief. These substances, which are not traditional painkillers, act through unique, non-traditional mechanisms that are usefully understood through mechanism-based nomenclature.

Journal of Oral RehabilitationVol. 53(2)
Tokyo Medical and Dental University (JP)
Openalex Percentile: Top 57%
Coffee research and impacts
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A Pharmacological and Critical Review of Caffeine and Alpha‐Lipoic Acid for Burning Mouth Syndrome — Takahiko Nagamine · Journal of Oral Rehabilitation (2025) | TGRS Research Map | TGRS