Outside Front Cover: Regulating Promiscuous Catalysis via Substrate‐Induced Transient Assembly (Angew. Chem. Int. Ed. 1/2026)
Transient substrate-induced co-assembly between a lysine-rich peptide and Fmoc-glycine is reported in the Communication (e202511352) by David Y.W. Ng, Tanja Weil, and co-workers. The non-equilibrium nanostructure creates a reactive microenvironment enabling promiscuous amino-acid-driven hydrolysis and C═N condensation reactions. Cleavage of the labile Fmoc group triggers collapse of the assembly, illustrating how broad prebiotic catalysis could have emerged under kinetic control.
Authors
- Maximilian Schuler
- Christopher V. Synatschke (ORCID: https://orcid.org/0000-0002-4259-6696)
- David Y. W. Ng (ORCID: https://orcid.org/0000-0002-0302-0678)
- Tanja Weil (ORCID: https://orcid.org/0000-0002-5906-7205)
- Jiyao Yu (ORCID: https://orcid.org/0000-0002-2103-3552)
- Qi Lu (ORCID: https://orcid.org/0000-0002-6191-3749)
- Ayan Chatterjee (ORCID: https://orcid.org/0000-0003-4699-7742)
- Marius G. Braun
Institutions
- Max Planck Institute for Polymer Research (DE)
- Max Planck School Matter to Life
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1002/anie.2025-m0512055500
- Primary Topic
- Supramolecular Self-Assembly in Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00