Outside Front Cover: An Orthogonal Nucleic Acid/Peptide Amplification Circuit Enables Protease‐Triggered, Cancer Cell‐Selective PD‐L1 Imaging (Angew. Chem. Int. Ed. 4/2026)
In the Research Article (e20284), Jian Zhao, Lele Li, and co-workers report an orthogonal hybrid circuit though PNA-directed engineering of DNA signal amplification technology with cleavable peptides, enabling cancer cell-selective PD-L1 imaging via aptamer-mediated recognition of membrane protein and protease-triggered hybridization chain reaction.
Authors
- Bo Wu (ORCID: https://orcid.org/0000-0003-1775-1698)
- Lele Li (ORCID: https://orcid.org/0000-0001-8593-9292)
- Jian Zhao (ORCID: https://orcid.org/0000-0001-5179-9914)
- Xiulin Yi (ORCID: https://orcid.org/0000-0001-7918-548X)
Institutions
- National Center for Nanoscience and Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1002/anie.2025-m0512060700
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00