Role of excessive fructose consumption on liver health

<h2>Abstract</h2> Non-alcoholic fatty liver disease (NAFLD) refers to a group of conditions characterized by excessive accumulation of fat in the liver in people with low or no alcohol consumption. The simplest or most common form of this condition is fatty liver, a non-serious condition in which fat is deposited in liver cells, where fructose and glucose play an influential role in this condition, and excessive fructose consumption can lead to lipid accumulation in the liver, which is associated with the development of non-alcoholic fatty liver disease. It has been significantly related to the intake of added fructose in the diet, being considered a relevant risk factor for its development, obesity, as well as other liver-related diseases. With the increasing availability of high-calorie foods, the use of fructose as a sweetener has been implicated in the increasing prevalence of NAFLD and metabolic syndrome. NAFLD may be benign in many cases, an increasing percentage of patients may progress to non-alcoholic steatohepatitis (NASH), which is characterized by inflammation and liver damage. In the context of NAFLD, poor glucose management may contribute to fat accumulation in the liver, one of the key factors in the development of this disease.