False Positive or False Negative—An Interesting Case in Prenatal Diagnostic Laboratory

Different diagnostic techniques possess distinct strengths, limitations, and applicable scopes. Certain abnormalities may evade detection by a single technique due to technical constraints or sample-specific biological characteristics. Therefore, in prenatal diagnosis, clinicians should select suitable diagnostic modalities based on clinical context. When necessary, multiple complementary methods should be employed for cross-validation to approximate the true fetal status and avoid missed diagnoses and misdiagnoses.