Retrospective Evaluation of Regenerative Endodontic Treatment of Teeth With Open Apices and Necrotic Pulps

This study retrospectively evaluated the outcomes of regenerative endodontic treatment (RET) of necrotic immature permanent teeth. Twenty teeth treated between 2015 and 2019 were included. RET was performed by disinfecting the canals, inducing apical bleeding, and placing platelet-rich fibrin (PRF) or concentrated growth factor (CGF) as a scaffold. Peri-apical radiographs were analysed using ImageJ software. The relationships between aetiology, gender, root development, apical closure and response to electrical pulp testing were statistically evaluated. Peri-apical healing was observed in all patients. Twelve teeth showed an increase in root length, whereas 16 exhibited an increase in root width. Eight teeth responded positively to the electric pulp test (EPT). A statistically significant correlation was found between apical closure and response to pulp sensibility testing (p = 0.019). The maximum increases in root length and width were 2.984 and 0.729 mm, respectively. The results confirm the potential of RET to promote continued root development and restore pulp vitality.