Non‐Syndromic Hereditary Gingival Fibromatosis Driven by Chymase Deficiency Is Attenuated by Verteporfin‐Loaded Exosomes
Our findings support the pathogenic role of the CHYMASE mutation in nsHGF, establish chymase deficiency and consequent YAP/TAZ activation as the underlying mechanism and propose verteporfin-loaded exosomes as a promising therapeutic strategy for nsHGF-associated gingival overgrowth.
Authors
- Bingyan Guo (ORCID: https://orcid.org/0000-0002-6625-229X)
- Yungshan Teng
- Wenfeng Li (ORCID: https://orcid.org/0000-0001-8819-6009)
- Danying Chen (ORCID: https://orcid.org/0000-0001-9730-1536)
- Yang Cao (ORCID: https://orcid.org/0000-0003-1613-4516)
- Yuqing Guo (ORCID: https://orcid.org/0000-0002-2989-3178)
- Ruoyu Li (ORCID: https://orcid.org/0000-0003-1451-3598)
- Runze Li (ORCID: https://orcid.org/0000-0003-2543-3032)
- Xin Chen (ORCID: https://orcid.org/0000-0001-7887-8401)
- Ziwei Huang (ORCID: https://orcid.org/0000-0002-6994-9017)
- Chen Zhou (ORCID: https://orcid.org/0000-0003-2277-8553)
- Ying Qing (ORCID: https://orcid.org/0000-0002-9551-8907)
- Weicai Wang (ORCID: https://orcid.org/0000-0002-0601-2497)
- Haotian Luo (ORCID: https://orcid.org/0000-0003-0747-0657)
- Hio Cheng Ieong
Institutions
- Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1111/jcpe.70077
- Primary Topic
- Oral and gingival health research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province