Mapping Molecular Diversity in Prostate Cancer With a Combined Multiplex IHC and RNA‐ISH Assay
This dual IHC and dual RNA-ISH approach represents a novel and reliable platform for multiplex detection of key prostate cancer biomarkers on a single slide. The method offers significant advantages for molecular classification, tissue-based biomarker validation, and comprehensive evaluation of tumor heterogeneity in translational and diagnostic research.
Authors
- Sean R. Williamson (ORCID: https://orcid.org/0000-0002-3898-1460)
- Nallasivam Palanisamy (ORCID: https://orcid.org/0000-0002-0633-9772)
- Nilesh Gupta (ORCID: https://orcid.org/0000-0002-3740-5947)
- Shannon Carskadon (ORCID: https://orcid.org/0000-0002-6950-0308)
- Sangeetha Jyothilingam (ORCID: https://orcid.org/0009-0003-6533-4108)
Institutions
- Cleveland Clinic (US)
- Henry Ford Health System (US)
- Spanish Oncology Genitourinary Group (ES)
Publication Details
- Journal
- The Prostate
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1002/pros.70108
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Congressionally Directed Medical Research Programs