Methodology for the Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study
If this study demonstrates that an EMS patient care protocol with age-based midazolam dosing is safe and more effective than current practice, the potential impact of this study is a paradigm shift in the treatment of pediatric seizures that can be easily implemented in EMS systems across the country. Beyond seizures, the concept of age-based dosing may also be applicable to other commonly encountered pediatric prehospital conditions for which medication may be indicated.
Authors
- Caleb E. Ward (ORCID: https://orcid.org/0000-0001-5272-8552)
- Graham Brant‐Zawadzki (ORCID: https://orcid.org/0000-0001-7842-8822)
- Kathryn M. Kothari (ORCID: https://orcid.org/0009-0002-2910-3583)
- Jonathan R. Studnek
- James J. Riviello (ORCID: https://orcid.org/0000-0002-4399-0257)
- Daniel K. Nishijima (ORCID: https://orcid.org/0000-0003-4952-8212)
- Rachel Munn
- Henry E. Wang (ORCID: https://orcid.org/0000-0002-4738-0093)
- Kathleen Adelgais (ORCID: https://orcid.org/0000-0002-4405-0769)
- Manish I. Shah (ORCID: https://orcid.org/0000-0003-0886-8747)
- Christian Martin‐Gill (ORCID: https://orcid.org/0000-0002-3522-2100)
- Kimia Ghaffari (ORCID: https://orcid.org/0009-0009-4748-144X)
- Catherine R. Counts (ORCID: https://orcid.org/0000-0002-7152-8887)
- Rana Said
- Nancy Glober (ORCID: https://orcid.org/0000-0001-5769-3651)
- Neomi Sepulveda
- Lindsey A. Morgan (ORCID: https://orcid.org/0000-0003-2206-5561)
- Brian M. Clemency (ORCID: https://orcid.org/0000-0002-7610-3087)
- Nicholas Patrick
- James M. Chamberlain (ORCID: https://orcid.org/0000-0003-0543-1814)
- Mohsen Saidinejad (ORCID: https://orcid.org/0000-0002-4782-0597)
- John M. VanBuren (ORCID: https://orcid.org/0000-0003-1350-5764)
- Joseph Sullivan (ORCID: https://orcid.org/0000-0003-2081-8988)
- Robert A. Lowe (ORCID: https://orcid.org/0000-0002-4732-9634)
- Claudia R. Morris (ORCID: https://orcid.org/0000-0001-8304-5244)
- K. Li (ORCID: https://orcid.org/0000-0002-2545-0329)
- Raymond L. Fowler
Institutions
- Indiana University Health (US)
- George Washington University Hospital (US)
- Children's National (US)
- University of Arizona (US)
- Oregon Health & Science University (US)
- University of Pittsburgh (US)
- Palo Alto University (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- George Washington University (US)
- University of Washington (US)
- University of Utah (US)
- UCLA Medical Center (US)
- University of Washington Medical Center (US)
- Los Angeles Medical Center (US)
- Family and Social Services Administration (US)
- Columbus Center (US)
- Stanford Medicine (US)
- Children's Healthcare of Atlanta (US)
- Wake County Human Services (US)
- The University of Texas Health Science Center (US)
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- University at Buffalo, State University of New York (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Trials
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s13063-025-09342-3
- Citations
- 1
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 2.25