TMEM151A in forebrain excitatory neurons negatively regulates seizure susceptibility
Cell type-specific knockout and overexpression experiments reveal that TMEM151A in forebrain excitatory neurons functions as a key regulator of seizure susceptibility. These results identify TMEM151A as a critical molecular determinant of neuronal network excitability and a potential therapeutic target for epilepsy.
Authors
- Yu‐Xian Zhang (ORCID: https://orcid.org/0009-0005-1796-1443)
- Xiuling Ma (ORCID: https://orcid.org/0009-0007-3679-3769)
- Zhi‐Ying Wu (ORCID: https://orcid.org/0000-0003-2106-572X)
- Bin Lu (ORCID: https://orcid.org/0000-0003-1456-2517)
- Zhi‐Qi Xiong (ORCID: https://orcid.org/0000-0001-7727-8412)
- Qiwu Xu (ORCID: https://orcid.org/0000-0003-2236-8415)
- J. C. He (ORCID: https://orcid.org/0009-0002-3342-9877)
- H. Zhou (ORCID: https://orcid.org/0009-0001-1513-4429)
- Ling Zhuang (ORCID: https://orcid.org/0009-0007-6846-883X)
Institutions
- ShanghaiTech University (CN)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University of Chinese Academy of Sciences (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1111/epi.70016
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00