A predictive model for life-threatening fluoropyrimidine toxicity based on <i>DPYD</i> sequencing in colorectal cancer
DPYD sequencing identified additional relevant variants and improved the sensitivity of DPYD testing. An online calculator (https://fluoropyrimidine-toxicity-predictor.gustaveroussy.fr/) is provided to estimate the individual probability of developing life-threatening toxicity, based on clinical covariates and extended DPYD genotype.
Authors
- Gwénaël Le Teuff (ORCID: https://orcid.org/0000-0003-3292-0939)
- Marie-Christine Étienne-Grimaldi (ORCID: https://orcid.org/0000-0002-0758-311X)
- Eva Seutin
- Yves Akoli Koudou
- Jean‐Pierre Desvignes (ORCID: https://orcid.org/0000-0003-3142-1994)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Yvonne Wettergren (ORCID: https://orcid.org/0000-0001-8660-7169)
- Valérie Boige (ORCID: https://orcid.org/0000-0002-7817-4663)
- Stephen P. Ackland (ORCID: https://orcid.org/0000-0001-5303-0017)
- Estelle Menoret
- Nathalie Cozic (ORCID: https://orcid.org/0000-0002-1509-528X)
- Matthias Schwab (ORCID: https://orcid.org/0000-0002-9984-075X)
- Anne Sudaka (ORCID: https://orcid.org/0000-0001-5729-0465)
- Christophe Béroud (ORCID: https://orcid.org/0000-0003-2986-8738)
- Barbara Jennings (ORCID: https://orcid.org/0000-0003-3792-9182)
- Pierre Laurent‐Puig (ORCID: https://orcid.org/0000-0001-8475-5459)
- Jean-Christophe Boyer
Institutions
- University of East Anglia (GB)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Côte d'Azur (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Newcastle College (GB)
- Sahlgrenska University Hospital (SE)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Institut de Chimie de Nice (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Centre de Recherche des Cordeliers (FR)
- Universitätsklinikum Tübingen (DE)
- La Ligue Contre le Cancer (FR)
- Region Västra Götaland (SE)
- Hôpital Européen Georges-Pompidou (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hôpital Européen (FR)
- Translational Research in Oncology (FR)
- Business Region Göteborg (Sweden) (SE)
- Laboratoire d'études sur les monothéismes (FR)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- Cognition Behaviour Technology (FR)
- Centre Antoine Lacassagne (FR)
- University of Newcastle Australia (AU)
- University of Tübingen (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/jnci/djaf357
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00