Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis
The study found no evidence to suggest that pharmacological BP-lowering therapy in individuals with IDH is less or more effective than in those without IDH. Relative risk reductions also did not diminish in those with lower diastolic BP, down to <60 mmHg at baseline. No meaningful differences across various clinical phenotypes were detected.
Authors
- Ajay Gupta (ORCID: https://orcid.org/0000-0001-5807-8503)
- Seiji Umemoto (ORCID: https://orcid.org/0000-0002-1970-8979)
- Wiek H. van Gilst (ORCID: https://orcid.org/0000-0003-2968-8585)
- Craig S. Anderson (ORCID: https://orcid.org/0000-0002-7248-4863)
- William C. Cushman (ORCID: https://orcid.org/0000-0001-7162-2972)
- Ji‐Guang Wang (ORCID: https://orcid.org/0000-0001-8511-1524)
- Yutaka Imai (ORCID: https://orcid.org/0000-0003-3925-8837)
- Yoshihiko Kanno (ORCID: https://orcid.org/0000-0003-2481-2372)
- John B. Kostis (ORCID: https://orcid.org/0000-0002-0335-3827)
- Kenji Ueshima
- Anthony Rodgers (ORCID: https://orcid.org/0000-0003-1282-1896)
- Barry M. Brenner
- Kazem Rahimi (ORCID: https://orcid.org/0000-0002-4807-4610)
- Salim Yusuf (ORCID: https://orcid.org/0000-0003-4776-5601)
- Peter M. Rothwell (ORCID: https://orcid.org/0000-0001-9739-9211)
- Lars Lindholm (ORCID: https://orcid.org/0000-0002-1633-2179)
- Hiromi Rakugi (ORCID: https://orcid.org/0000-0001-6508-4338)
- Jasper J. Brugts (ORCID: https://orcid.org/0000-0002-5522-9318)
- Giuseppe Remuzzi (ORCID: https://orcid.org/0000-0002-6194-3446)
- Hiroshi Ogawa (ORCID: https://orcid.org/0000-0002-2576-2525)
- Stephen MacMahon (ORCID: https://orcid.org/0000-0003-2064-7699)
- Vlado Perkovic (ORCID: https://orcid.org/0000-0002-4257-7620)
- Steven Nissen
- Colin Baigent (ORCID: https://orcid.org/0000-0003-4856-7420)
- Jan Lanke
- Ettore Malacco
- Stephan Lueders
- Nigel Beckett (ORCID: https://orcid.org/0000-0002-7736-3817)
- Mark Woodward (ORCID: https://orcid.org/0000-0001-9800-5296)
- Keith A.A. Fox (ORCID: https://orcid.org/0000-0002-0140-2752)
- Folkert W. Asselbergs (ORCID: https://orcid.org/0000-0002-1692-8669)
- Kristian Wachtell (ORCID: https://orcid.org/0000-0001-5861-1478)
- Alberto Zanchetti (ORCID: https://orcid.org/0000-0003-4796-7959)
- Barry R. Davis (ORCID: https://orcid.org/0000-0002-6943-5673)
- Bertram Pitt (ORCID: https://orcid.org/0000-0001-5880-275X)
- Jan A. Staessen (ORCID: https://orcid.org/0000-0002-3026-1637)
- Dick de Zeeuw (ORCID: https://orcid.org/0000-0003-3434-7777)
- Edmund J. Lewis (ORCID: https://orcid.org/0009-0001-0323-3083)
- Dexter Canoy (ORCID: https://orcid.org/0000-0003-4493-9901)
- Paul K. Whelton (ORCID: https://orcid.org/0000-0002-2225-383X)
- Rury R. Holman (ORCID: https://orcid.org/0000-0002-1256-874X)
- Koon Kang Teo (ORCID: https://orcid.org/0000-0002-3731-0956)
- Ale Algra (ORCID: https://orcid.org/0000-0003-2858-5808)
- John Chalmers (ORCID: https://orcid.org/0000-0002-9931-0580)
- Julia B. Lewis (ORCID: https://orcid.org/0000-0002-1530-7115)
- Marc Allan Pfeffer
- Jacobus Lubsen
- Christopher M. Reid (ORCID: https://orcid.org/0000-0001-9173-3944)
- Piero Ruggenenti (ORCID: https://orcid.org/0000-0002-8394-0879)
- Masao Ishii (ORCID: https://orcid.org/0000-0002-7328-4599)
- Amanda Adler (ORCID: https://orcid.org/0000-0002-2797-3385)
- Carl J. Pepine (ORCID: https://orcid.org/0000-0002-6011-681X)
- Jamie P. Dwyer (ORCID: https://orcid.org/0000-0002-8402-8961)
- Zeinab Bidel (ORCID: https://orcid.org/0000-0002-8852-1622)
- Paolo Verdecchia (ORCID: https://orcid.org/0000-0002-4135-8936)
- Frank P. Brouwers (ORCID: https://orcid.org/0000-0003-0518-2387)
- Rusitanmujiang Maimaitiaili (ORCID: https://orcid.org/0009-0006-8524-4961)
- Lutgarde Thijs (ORCID: https://orcid.org/0000-0002-8108-2356)
- Neil R Poulter (ORCID: https://orcid.org/0000-0002-6292-997X)
- Lindon Wing
- Takayoshi Ohkubo (ORCID: https://orcid.org/0000-0002-3283-8196)
- Johan Sundström (ORCID: https://orcid.org/0000-0003-2247-8454)
- Bruce Charles Neal (ORCID: https://orcid.org/0000-0002-0490-7465)
- Gianpaolo Reboldi (ORCID: https://orcid.org/0000-0002-9877-0702)
- Hiromichi Suzuki (ORCID: https://orcid.org/0000-0003-1434-7104)
- Toshio Ogihara (ORCID: https://orcid.org/0000-0002-7119-7192)
- Milad Nazarzadeh (ORCID: https://orcid.org/0000-0002-0576-8874)
- John W. McEvoy (ORCID: https://orcid.org/0000-0001-6530-5479)
- Joachim Schrader
- Giuseppe Mancia (ORCID: https://orcid.org/0000-0003-0942-3176)
- Anushka Patel (ORCID: https://orcid.org/0000-0003-3825-4092)
- Peter Sever
- Sverre E. Kjeldsen (ORCID: https://orcid.org/0000-0003-2389-0272)
- Eric H. Boersma (ORCID: https://orcid.org/0000-0002-2559-7128)
- Rory Collins (ORCID: https://orcid.org/0000-0001-8288-8602)
- Zhen‐Yu Zhang
- Tsuguya Fukui (ORCID: https://orcid.org/0009-0009-2835-8892)
- Maria H. Mehlum (ORCID: https://orcid.org/0000-0002-8885-2798)
- Christopher R. Palmer
- Robert P. Byington
- Masunori Matsuzaki
- Gholamreza Salimi-Khorshidi
- Morris J. Brown (ORCID: https://orcid.org/0000-0001-8409-1082)
- Takao Saruta
- Jeffrey A. Cutler
- Robert W. Schrier
- Eivind Berge
- Henry R. Black
- Larry Agodoa
- Giancarlo Viberti
- Peter Sleight
- Kizuku Kuramoto
- Robert Fagard
- Fiona Turnbull
- Yoshiki Yui
- Ray Estacio
- Richard B Devereaux
- Michel Lièvre
- Stevo Julius
- Christopher J. Bulpitt
Institutions
- Tongji University (CN)
- Ollscoil na Gaillimhe – University of Galway (IE)
- University Hospital Galway (IE)
- Population Health Research Institute (CA)
- UNSW Sydney (AU)
- University of Florida (US)
- University of Oxford (GB)
- The George Institute for Global Health (AU)
- Shanghai Tenth People's Hospital (CN)
- COPE Galway (IE)
- Hamilton Health Sciences (CA)
- Newcastle University (GB)
- The University of Texas Health Science Center at Houston (US)
- McMaster University (CA)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1093/eurheartj/ehaf962
- Citations
- 2
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78