Key Early Changes in Oral Squamous Cell Carcinogenesis Are Accelerated by Ectopic BMI1 Expression
Most OSCC diagnoses occur in advanced stages. Our data indicate that BMI1 overexpression, as detected in premalignant oral lesions, increases proliferation, oxidative stress, and expression of human OSCC-associated targets in our murine model after a short, 4-week carcinogen treatment. Thus, BMI1 could be a potential target for cancer prevention approaches.
Authors
- Theresa Scognamiglio (ORCID: https://orcid.org/0000-0001-6200-0231)
- Daniel Galke (ORCID: https://orcid.org/0009-0000-5997-991X)
- Xiao-Han Tang (ORCID: https://orcid.org/0000-0001-9610-6608)
- Lorraine J. Gudas (ORCID: https://orcid.org/0000-0003-3115-4777)
- Jorge Baquero (ORCID: https://orcid.org/0000-0001-9338-3407)
- Tuo Zhang (ORCID: https://orcid.org/0000-0001-5396-918X)
Institutions
- Cornell University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0580
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Weill Cornell Medical College