Prospective Validation of Circulating Tumor DNA Measurable Residual Disease After First-Line Therapy in Large B-Cell Lymphoma

This study validates ultrasensitive ctDNA-MRD detection using PhasED-Seq in a uniformly treated, prospective real-world LBCL cohort. These findings support further evaluation of MRD integration into clinical response assessment.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2025-12-12
DOI
https://doi.org/10.1200/jco-25-01712
Citations
2
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
2.94
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article

Prospective Validation of Circulating Tumor DNA Measurable Residual Disease After First-Line Therapy in Large B-Cell Lymphoma

Ad Koster, Rinske Boersma, Ash A. Alizadeh, Martine E.D. Chamuleau et al.
2 citations
Journal of Clinical Oncology
Lymphoma Diagnosis and Treatment
2.94
article

Prospective Validation of Circulating Tumor DNA Measurable Residual Disease After First-Line Therapy in Large B-Cell Lymphoma

Ad Koster, Rinske Boersma, Ash A. Alizadeh, Martine E.D. Chamuleau, Sierra M. Love Stowell, Stephanie Meek, Marcel Nijland, Leonie Strobbe, Marjolein van der Poel, Erik D. van Werkhoven, D. Michiel Pegtel, Avinash G. Dinmohamed, Clara Klerk, David M. Kurtz, Margriet Oosterveld, Eva de Jongh, Helma G.J.M. Zanders, Steven Wang, Hans F. M. Pruijt, Harry R. Koene, Hayley Warinske
article en
2 citations

Abstract

This study validates ultrasensitive ctDNA-MRD detection using PhasED-Seq in a uniformly treated, prospective real-world LBCL cohort. These findings support further evaluation of MRD integration into clinical response assessment.

Journal of Clinical OncologyVol. 44(5)
University Medical Center Groningen (NL), Gelre Hospitals (NL), Maastricht University (NL), Albert Schweitzer Ziekenhuis (NL), St. Antonius Ziekenhuis (NL), Amphia Ziekenhuis (NL), Canisius-Wilhelmina Ziekenhuis (NL), VieCuri Medisch Centrum (NL), Netherlands Comprehensive Cancer Organisation (NL), Foresight Science & Technology (United States) (US), Hovon (NL), Jeroen Bosch Ziekenhuis (NL), Vrije Universiteit Amsterdam (NL), Stanford University (US)
Openalex Percentile: Top 8%
Lymphoma Diagnosis and Treatment
2.94
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