Prospective Validation of Circulating Tumor DNA Measurable Residual Disease After First-Line Therapy in Large B-Cell Lymphoma
This study validates ultrasensitive ctDNA-MRD detection using PhasED-Seq in a uniformly treated, prospective real-world LBCL cohort. These findings support further evaluation of MRD integration into clinical response assessment.
Authors
- Ad Koster
- Rinske Boersma (ORCID: https://orcid.org/0000-0003-1713-8666)
- Ash A. Alizadeh (ORCID: https://orcid.org/0000-0002-5153-5625)
- Martine E.D. Chamuleau (ORCID: https://orcid.org/0000-0002-0123-9182)
- Sierra M. Love Stowell (ORCID: https://orcid.org/0000-0003-4376-2569)
- Stephanie Meek (ORCID: https://orcid.org/0000-0002-2738-6578)
- Marcel Nijland (ORCID: https://orcid.org/0000-0002-2740-2873)
- Leonie Strobbe
- Marjolein van der Poel (ORCID: https://orcid.org/0000-0002-1305-4150)
- Erik D. van Werkhoven (ORCID: https://orcid.org/0000-0001-7469-7427)
- D. Michiel Pegtel (ORCID: https://orcid.org/0000-0002-7357-4406)
- Avinash G. Dinmohamed (ORCID: https://orcid.org/0000-0002-4767-6716)
- Clara Klerk
- David M. Kurtz (ORCID: https://orcid.org/0000-0002-6382-4651)
- Margriet Oosterveld (ORCID: https://orcid.org/0000-0002-6742-9261)
- Eva de Jongh (ORCID: https://orcid.org/0000-0001-7316-029X)
- Helma G.J.M. Zanders
- Steven Wang (ORCID: https://orcid.org/0000-0001-5473-9415)
- Hans F. M. Pruijt (ORCID: https://orcid.org/0000-0002-2067-6791)
- Harry R. Koene
- Hayley Warinske
Institutions
- University Medical Center Groningen (NL)
- Gelre Hospitals (NL)
- Maastricht University (NL)
- Albert Schweitzer Ziekenhuis (NL)
- St. Antonius Ziekenhuis (NL)
- Amphia Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- VieCuri Medisch Centrum (NL)
- Netherlands Comprehensive Cancer Organisation (NL)
- Foresight Science & Technology (United States) (US)
- Hovon (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Vrije Universiteit Amsterdam (NL)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1200/jco-25-01712
- Citations
- 2
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94