The alternative splicing landscape of hepatocellular carcinoma and its potential for HCC detection
This study provides a comprehensive characterization of ASEs in HCC and highlights their potential as circulating biomarkers. Our findings support the utility of ASEs in CECs for HCC detection, particularly in combination with AFP, although additional studies are needed to validate these ASEs in an independent prospective cohort. Finally, we introduce HCC-INSIGHT as a resource for further research into HCC splicing alterations.
Authors
- Courtney E. Hershberger (ORCID: https://orcid.org/0000-0002-2195-989X)
- Noah J. Daniels (ORCID: https://orcid.org/0000-0002-1688-0933)
- Daniel Miller Rotroff (ORCID: https://orcid.org/0000-0003-0553-3220)
- William M. Patterson (ORCID: https://orcid.org/0000-0002-1922-5555)
Institutions
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1097/hc9.0000000000000838
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00