Age-varying DNA methylation patterns associated with blood pressure across the lifespan
Blood-derived DNA methylation shows dynamic age-related associations with blood pressure that likely reflect systemic or vascular aging processes rather than direct cellular mediation. Longitudinal analytical frameworks can reveal temporal patterns in epigenetic variation that are not detectable in single time point studies and may inform the discovery of biomarkers for age related cardiovascular risk.
Authors
- Zuoheng Wang (ORCID: https://orcid.org/0000-0002-7251-3687)
- Edwin C. Oh (ORCID: https://orcid.org/0000-0002-6042-1478)
- Amei Amei (ORCID: https://orcid.org/0000-0003-1045-2345)
- Xiaowei Zhuang (ORCID: https://orcid.org/0000-0002-6034-7853)
- Gang Xu (ORCID: https://orcid.org/0000-0001-9866-5438)
Institutions
- Cleveland Clinic (US)
- University of Nevada, Las Vegas (US)
- Lou Ruvo Brain Institute (US)
- Yale University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-12
- DOI
- https://doi.org/10.64898/2025.12.09.693332
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00