MYBL2 regulates the expression of CENPF in lung adenocarcinoma and promotes tumor development and metastasis through AKT pathway activation
The expression of MYBL2 and CENPF in lung adenocarcinoma increases with LUAD progression. MYBL2 regulates the expression of CENPF in LUAD, and the elevated CENPF promotes the proliferation and migration of LUAD cells. Both MYBL2 and CENPF regulate the proliferation and migration of LUAD through AKT pathway activation.
Authors
- Yan Liu (ORCID: https://orcid.org/0000-0002-3961-9172)
- Feng Yu (ORCID: https://orcid.org/0009-0002-1580-1110)
- Hongmei Ma (ORCID: https://orcid.org/0000-0002-5028-8060)
- Jiuyang Jiang (ORCID: https://orcid.org/0009-0001-1674-8342)
Institutions
- Union Hospital (HK)
- Harbin Medical University (CN)
- Xiamen Chang Gung Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s40001-025-03648-3
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00