Enhancing Deinagkistrodon acutus antivenom potency through acutolysin A-targeted antibody supplementation
Collectively, our results highlight anti-acutolysin A antibodies as key determinants of D. acutus antivenom potency and demonstrate that their targeted supplementation can enhance neutralization efficacy, supporting antibody-based enhancement as a potential strategy to improve the potency of D. acutus antivenoms.
Authors
- Lichieh Julie Chu (ORCID: https://orcid.org/0000-0002-8488-9614)
- Hsiao-Yun Chao
- Chien-Chun Liu (ORCID: https://orcid.org/0000-0002-2324-7976)
- Cho-Ju Wu (ORCID: https://orcid.org/0009-0002-7991-2434)
- Chi Yang (ORCID: https://orcid.org/0000-0002-1676-5185)
- Ruchao Peng (ORCID: https://orcid.org/0000-0002-2741-6212)
- Yi-Xiu Yang
- Yu-Shao Chou (ORCID: https://orcid.org/0000-0003-3205-2385)
- Min-Xian Li
- Yen-Chang Hsiao (ORCID: https://orcid.org/0000-0003-0046-3016)
- Zhongyi Yan (ORCID: https://orcid.org/0000-0002-9356-2699)
Institutions
- Chang Gung University (TW)
- En Chu Kong Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Xiamen Chang Gung Hospital (CN)
- Xiamen Medical College
- Xiamen University of Technology (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1371/journal.pntd.0013847
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00