FDG-PET–Based Selective Deescalation of Chemoradiation in Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial
FDG-PET-based RT dose personalization resulted in promising LRR outcomes in early-stage oropharynx cancer with improved short-term patient-reported outcomes. Furthermore, HPV ctDNA changes early in treatment may predict LRC.
Authors
- Collin Brummel (ORCID: https://orcid.org/0000-0001-7198-8560)
- Heather M. Walline (ORCID: https://orcid.org/0000-0003-3790-5738)
- Benjamin Rosen (ORCID: https://orcid.org/0000-0002-7827-4197)
- Chaz L. Stucken (ORCID: https://orcid.org/0000-0003-1448-3376)
- Yue Cao (ORCID: https://orcid.org/0000-0003-3910-3261)
- Francis P. Worden (ORCID: https://orcid.org/0000-0002-6632-4951)
- Samuel N. Regan (ORCID: https://orcid.org/0000-0002-5449-8348)
- Ka Kit Wong (ORCID: https://orcid.org/0009-0006-0837-7816)
- Krithika Suresh (ORCID: https://orcid.org/0000-0001-7785-3536)
- Keith Casper (ORCID: https://orcid.org/0000-0003-2878-3863)
- Kelly M. Malloy (ORCID: https://orcid.org/0000-0002-0337-9293)
- Mark E. Prince (ORCID: https://orcid.org/0000-0002-1120-9008)
- David Forner (ORCID: https://orcid.org/0000-0002-1014-3545)
- Theodore S. Lawrence (ORCID: https://orcid.org/0000-0002-4186-8821)
- Pratyusha Yalamanchi (ORCID: https://orcid.org/0000-0003-0776-3759)
- Paul Swiecicki (ORCID: https://orcid.org/0000-0003-2286-3555)
- Andrew G. Shuman (ORCID: https://orcid.org/0000-0002-9305-7860)
- Madhava Aryal (ORCID: https://orcid.org/0000-0003-3938-1843)
- Muneesh Tewari (ORCID: https://orcid.org/0000-0002-7781-3152)
- Michelle Mierzwa (ORCID: https://orcid.org/0000-0002-3923-9970)
- Jennifer Shah (ORCID: https://orcid.org/0000-0002-3847-8865)
- Marisa R. Buchakjian (ORCID: https://orcid.org/0000-0001-8261-1566)
- J. Chad Brenner (ORCID: https://orcid.org/0000-0003-3238-1111)
- Steven Bennett Chinn (ORCID: https://orcid.org/0000-0003-4282-0640)
- Molly E. Heft Neal (ORCID: https://orcid.org/0000-0002-8813-5537)
- Chandan Bhambhani (ORCID: https://orcid.org/0000-0001-9572-9328)
- R. Akhdar (ORCID: https://orcid.org/0009-0008-7045-8638)
- Arjun Dinesh (ORCID: https://orcid.org/0009-0003-2801-384X)
Institutions
- University of Michigan (US)
- Michigan United (US)
- Michigan Medicine (US)
- Ann Arbor Center for Independent Living (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2820
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00